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The Justice Department sued on Thursday to block the Anheuser-Busch InBev proposed $20.1 billion deal to buy control of Grupo Modelo of Mexico, arguing that the merger would significantly reduce competition in the American beer market.

The deal, announced last summer, would add Corona Extra to the company's formidable stable of brands, including Budweiser and Stella Artois.

But the Justice Department said in its lawsuit, filed in Federal District Court in Washington, that allowing the merger to proceed would reduce competition in the beer industry across the country as a whole and in 26 metropolitan areas in particular. The combined company would control about 46 percent of annual sales in the country, the government said, far outpacing Anheuser-Busch InBev's closest competitor, MillerCoors.

"If ABI fully owned and controlled Modelo, ABI would be able to increase beer prices to American consumers," William J. Baer, head of the Justice Department's antitrust division, said in a statement. "This lawsuit seeks to prevent ABI from eliminating Modelo as an important competitive force in the beer industry."

The deal is the biggest to be opposed by the Justice Department since 2011, when it sued to block the proposed $39 billion takeover by AT&T of T-Mobile USA.

The government's move is the first significant effort to halt widespread consolidation in the beer industry in some time. Anheuser-Busch InBev itself was the product of a blockbuster merger between two of the world's biggest brewers, and one of MillerCoors's parents is the acquisitive SABMiller.

In its complaint, the Justice Department said Modelo had served as a low-price counterbalance to its larger competitors, resisting the price increases Anheuser-Busch InBev has promoted regularly.

Anheuser-Busch InBev indicated that it intends to fight the lawsuit. The company said in a statement, "We remain confident in our position, and we intend to vigorously contest the DOJ's action in federal court."